hrp0089p1-p070 | Diabetes & Insulin P1 | ESPE2018

Birth Weight in Offsprings of Mothers with Gestational Diabetes Mellitus due to Mutations in GCK Gene

Zubkova Natalia , Burumkulova Fatima , Petrukhin Vasily , Plechanova Margarita , Panov Anton , Ulyatovskaya Victoria , Makretskaya Nina , Tiulpakov Anatoliy

Background: The prevalence of MODY2 in the gestational diabetic population has been estimated to be approximately 2%. Risk of macrosomia in GCK/GDM cases depends on maternal glycemic control and fetal mutation status. However, the fetal genotype is unknown before birth. We assessed the effects of insulin therapy on the birth weight of children born to mothers with GCK mutations.Objective and hypotheses: The study included 38 patients with GDM due to GCK ...